VascuSkin – Pre-vascularization of a three-dimensional fibrin gel matrix with orientated micro-yarns for an optimized skin development
The current treatment options for chronic or acute, as well as deep and extensive wounds are not satisfactory. As “gold standard” split-thickness skin grafts are used, which nevertheless contain many disadvantages. Beside the emergence of distinctive scar tissue the transplant quality is a serious problem. At large-scale defects >50-60% of the total body surface, the donor site morbidity is a further disadvantage. Therefore, an autologous full-thickness skin graft with physiologically functional and anatomical functions is desirable.
The aim of the project is the generation of a fibrin-based skin model, which will be used as autologous tissue graft prospectively. For a distinct and directed blood vessel orientation we resort to micro yarns in the form of spacer fabrics. The application of such fabrics should provide an optimized nutrition of thick tissues and organs.
The project is founded by the START- program of the RWTH Aachen University and is realized in cooperation with the Clinic for Dermatology and Allergology University Hospital RWTH as well as the Institute of Textile Engineering (ITA) of the RWTH Aachen University.