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Publikationen der Gruppe Angewandte Forschung


Bücher & Buchkapitel

2016

  • Clauser J, Gester K, Steinseifer U, Sonntag SJ. Regulation Blood Cell Adhesion via Surface Modification of Polyurethanes. In: Cooper SL, Guan J. Advances in Polyurethane Biomaterials, pp. 287 - 318. Woodhead Publishing, 2016.

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Journal-Beiträge

2016

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2015

  • Schlanstein PC, Hesselmann F, Jansen SV, Gemsa J, Kaufmann TA, Klaas M, Roggenkamp D, Schröder W, Schmitz-Rode T, Steinseifer U, and Arens J. Particle image velocimetry used to qualitatively validate computational fluid dynamic simulations in an oxygenator: A proof of concept. Cardiovascular Engineering and Technology, 2015; 1–12.
  • Jansen-Park SH, Mahmood MN, Müller I, Turnhoff LK, Schmitz-Rode T, Steinseifer U, Sonntag SJ. Effects of Interaction Between Ventricular Assist Device Assistance and Autoregulated Mock Circulation Including Frank-Starling Mechanism and Baroreflex. Artif Organs; 2015; Epub ahead of print.
  • Jansen SV, Müller I, Kiesendahl N, Schmitz-Rode T, Steinseifer U. Towards a Novel Spatially-Resolved Hemolysis Detection Method Using a Fluorescent Indicator and Loaded Ghost Cells: Proof-of-Principle. Cardiovasc Eng Technol, 2015;6(3), 376-82.

  • Sonntag SJ, Kütting M, Ghalati PF, Kaufmann T, Vázquez-Jiménez J, Steinseifer U, Vodiskar J. Effect of pulmonary conduit oversizing on hemodynamics in children. Int J Artif Organs, 2015; 38(10), 548-56.
  •  Gester K, Lüchtefeld I, Büsen M, Sonntag SJ, Linde T, Steinseifer U, Cattaneo G. In Vitro Evaluation of Intra-Aneurysmal, Flow-Diverter-Induced Thrombus Formation: A Feasibility Study. AJNR Am J Neuroradiol, 2015; Epub ahead of print.
    • Neidlin M, Büsen M, Brockmann C, Wiesmann M, Sonntag SJ, Steinseifer U, Kaufmann TA. A numerical framework to investigate hemodynamics during endovascular mechanical recanalization in acute stroke. Int J Numer Method Biomed Eng, 2015; Epub ahead of print.
    • Wu W, Pott D, Mazza B, Sironi T, Dordoni E, Chiastra C, Petrini L, Pennati G, Dubini G, Steinseifer U, Sonntag S, Kuetting M, Migliavacca F. Fluid-Structure Interaction Model of a Percutaneous Aortic Valve: Comparison with an In Vitro Test and Feasibility Study in a Patient-Specific Case. Ann Biomed Eng, 2015; Epub ahead of print.

    • Gester K, Birtel S, Clauser J, Steinseifer U, Sonntag SJ. Real-Time Visualization of Platelet Interaction With Micro Structured Surfaces. Artif Organs, 2015; Epub ahead of print.

    • Jansen SV, Müller I, Nachtsheim M, Schmitz-Rode T, Steinseifer U. Ghost Cell Suspensions as Blood Analogue Fluid for Macroscopic Particle Image Velocimetry Measurements. Artif Organs, 2015; Epub ahead of print.
    • Büsen M, Kaufmann TA, Neidlin M, Steinseifer U, Sonntag SJ. In vitro flow investigations in the aortic arch during cardiopulmonary bypass with stereo-PIV. J Biomech 2015, 16(10); 2005-11.

      • Gester K, Jansen SV, Stahl M, Steinseifer U. A simple method for the investigation of cell separation effects of blood with physiological hematocrit values. Artif Organs, 2015, 39 (5); 432-40.

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      2014

      • Clauser J, Gester K, Roggenkamp J, Mager I, Maas J, Jansen SV, Steinseifer U. Micro-structuring of polycarbonate-urethane surfaces in order to reduce platelet activation and adhesion. J. Biomater. Sci. Polym. Ed, 2014; 25(5):504-518.
      • Gester K, Jansen SV, Stahl M, Steinseifer U. A simple method for the investigation of cell separation effects of blood with physiological hematocrit values. Artif Organs, 2014; online published ahead of print.
      • Egger C. Das erworbene von-Willebrand-Syndrom bei ECLS-Patienten: Wie teste ich Blutpumpen und Oxygenatoren in vitro? Kardiotechnik, 2014; 1:3-7.
      • Sonntag SJ, Kaufmann TAS, Buesen MR, Laumen M, Gräf F, Linde T, Steinseifer U. Numerical washout study of a pulsatile Total Artificial Heart. Int. J. Artif. Organs, 2014; 37:241-252.
      • Sonntag SJ, Li W, Kaestner W, Becker M, Büsen MR, Marx N, Merhof D, Steinseifer U. Combined Computational and Experimental Approach to Improve the Assessment of Mitral Regurgitation by Echocardiography. Ann. Biomed. Eng., 2014; 42(5):971-985.
      • Kaufmann TAS, Neidlin M, Buesen M, Sonntag SJ, Steinseifer U. Implementation of Intrinsic Lumped Parameter Modeling into Computational Fluid Dynamicy Studies of Cardiopulmonary Bypass. J. Biomech., 2014; 47:729-735.
      • Kaufmann TAS, Schlanstein P, Moritz A, Steinseifer U. Development of a hemodynamically optimized outflow cannula for cardiopulmonary bypass. Artif. Organs, 2014; 38:972-978.
      • Neidlin M, Steinseifer U, Kaufmann TAS. A multiscale 0-D/3-D approach to patient-specific adaptation of a cerebral autoregulation model for computational fluid dynamics studies of cardiopulmonary bypass. J. Biomech., 2014; 47:1777-1783.
      • Neidlin M, Jansen S, Steinseifer U, Moritz A, Kaufmann TAS. Design Modifications and Computational Fluid Dynamic Analysis of an Outflow Cannula for Cardiopulmonary Bypass. Ann. Biomed. Eng., 2014; 42:2048-2057.
      • Kaufmann TAS, Leisser C, Gemsa J, Steinseifer U. Analysis of emboli and blood flow in the ophthalmic artery to understand retinal artery occlusion. Biomed Tech, 2014; 59(6):471–477.
      • Kaufmann TAS, Steinseifer U, Schmitz-Rode T. Computergestützte Modellierung in der kardiovaskulären Medizintechnik In: Braunschweigische Wissenschaftliche Gesellschaft: Jahrbuch 2013. J. Cramer Verlag; ISBN: 978-3-934656-33-8, 2014.

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      2013

      • Gester K, von Trotha K-T, Butz N, Neumann UP, Schmitz-Rode T, Steinseifer U. Investigation of tear-out behaviour of small inestinal anastomoses introducing a new standardization of the measurement procedure. J. Mech. Med. Biol., 2013; 13(1):1-13.
      • Sonntag SJ, Kaufmann TAS, Buesen MR, Laumen M, Linde T, Schmitz-Rode T, Steinseifer U. Simulation of a pulsatile total artificial heart: Development of a partitioned Fluid Structure Interaction model. J. Fluid. Struct., 2013; 38:187-204.
      • Hillebrand J, Dzemali O, Konerding MA, Koch M, Kaufmann TAS, Steinseifer U, Moritz A. Anatomical and flow dynamic considerations for safe right axillary artery cannulation. J. Thor. Cardiovasc. Surg., 2013; 146(2):467–471.

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      2012

      • Linde T, Hamilton KF, Cuenca Navalon E, Schmitz-Rode T, Steinseifer U. Aortic root compliance influences hemolysis in mechanical heart valve prostheses: an in-vitro study. Int J Artif Organs, 2012; 35(7):495-502.
      • Kaufmann TAS, Schmitz-Rode T, Steinseifer U. Implementation of Cerebral Autoregulation into Computational Fluid Dynamics Studies of Cardiopulmonary Bypass. Artif. Organs, 2012; 6(8):754-758.
      • Kaufmann TAS, Wong KC, Schmitz-Rode T, Steinseifer U. Mimicking of Cerebral Autoregulation by Flow-Dependent Cerebrovascular Resistance: a Feasibility Study. Artif. Organs, 2012; 36:97-101.
      • Kaufmann TAS, Schmitz-Rode T, Moritz A, Steinseifer U. Mimicking of the Human Regulatory System by Flow-Dependent Vascular Resistance: A Feasibility Study.In: C.T. Lim and J.C.H. Goh (Eds.): WCB 2010 IFMBE Proceedings 31/LXV, 2012.

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      2011

      • Gester K, Gabler C, von Trotha K-T, Butz N, Neumann UP, Schmitz-Rode T, Steinseifer U. Optical Strain Measurement and Tear-out Behavior of Sutured Porcine Small Intestine Tissue Using a Standardized Procedure. J. Med. Imaging Health Inf.,2011; 1(3):207-212.
      • Amor N, Hamilton K, Küppers M, Steinseifer U, Appelt S, Blümich B, Schmitz-Rode T. NMR and MRI of blood-dissolved hyperpolarized Xe-129 in different hollow-fiber membranes. Chemphyschem., 2011; 12(16):2941-2947.
      • Linde T, Hamilton KF, Timms DL, Schmitz-Rode T, Steinseifer U. A Low-Volume Tester for the Thrombogenic Potential of Mechanical Heart Valve Prostheses. J Heart Valve Dis., 2011; 20(5):510-517.
      • Kaufmann TAS, Linde T, Cuenca-Navalon E, Schmitz C, Hormes M, Schmitz-Rode T, Steinseifer U. Transient, three-dimensional flow field simulation through a mechanical, trileaflet heart valve prosthesis. ASAIO J. 2011;57(4):278-82.
      • Kaeberich A, Reindl I, Raaz U, Maegdefessel L, Vogt A, Linde T, Steinseifer U, Perzborn E, Hauroeder B, Buerke M, Werdan K, Schlitt A. Comparison of unfractionated heparin, low-molecular-weight heparin, low-dose and high-dose rivaroxaban in preventing thrombus formation on mechanical heart valves: results of an in vitro study. J Thromb Thrombolysis., 2011; 32:417-425.
      • Hormes M, Borchardt R, Mager I, Rode TS, Behr M, Steinseifer U. A validated CFD model to predict O2 and CO2; transfer within hollow fiber membrane oxygenators. Int J Artif Organs. 2011; 34(3):317-25.
      • Sonntag SJ. Numerische Simulation des Blutflusses an insuffizienten Mitralklappen. In Heinz Handels; Jan Ehrhardt; Thomas Martin Deserno; Hans-Peter Meinzer & Thomas Tolxdorff, ed., Bildverarbeitung für die Medizin, Springer, 2011.
      • Kaufmann TAS, Laumen M, Schlanstein P, Schmitz-Rode T, Steinseifer U. Combining imaging, CAD and CFD techniques to improve patient outcome during cardiopulmonary bypass and ventricular assist device support. Computer Aided Medical Engineering, 2011.
      • Kaufmann TAS, Graefe R, Hormes M, Schmitz-Rode T, Steinseifer U. Computational Fluid Dynamics in Biomedical Engineering. In: Computational Fluid Dynamics: Theory, Analysis and Applications. Murphy AD (Edt.), Nova Publishers; ISBN: 978-1-61209-276-8, 2011.

      • Kaufmann TAS, Gester K, von Trotha K-T, Butz N, Neumann UP, Schmitz-Rode T, Steinseifer U. Numerical simulation of suture tension dependent on fiber material and puncture modalities. In: Biomedical Engineering (MECBME), 2011 1st Middle East Conference on, 2011.

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      2010

      • Maegdefessel L, Linde T, Krapiec F, Hamilton K, Steinseifer U, van Ryn J, Raaz U, Buerke M, Werdan K, Schlitt A. In vitro comparison of dabigatran, unfractionated heparin, and low-molecular-weight heparin in preventing thrombus formation on mechanical heart valves. Thromb Res.,2010; 126:e196-200.
      • Spillner J, Hatam N, Amerini A, Otte F, Linde T, Krombach G, Autschbach R, Carpi A, Dohmen G. Stent-based, off-pump creation of an apico-aortic conduit. Frontiers in bioscience (Elite edition), 2010:1368-1373.
      • Jansen SV, Behbahani M, Laumen M, Kaufmann T. Hormes M. Schmitz-Rode T, Behr M, Steinseifer U. Investigation of steady flow through a realistic model of the thoracic human aorta using 3D stereo-PIV and CFD-simulation. ASAIO Journal., 2010; 56(2):98.

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       2009

      • Maegdefessel L, Linde T, Michel T, Hamilton K, Steinseifer U, Friedrich I, Schubert S, Hauroeder B, Raaz U, Buerke M, Werdan K, Schlitt A. Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves. Thrombosis and Haemostases, 2009; 101:1163-1169.
      • Kim CH, Steinseifer U, Schmitz-Rode T. Thrombogenic evaluation of two mechanical heart valve prostheses using a new in-vitro test system. J Heart Valve Dis., 2009; 18(2):207-213.
      • Kaufmann TAS, Hormes M, Laumen M, Timms DL, Linde T, Schmitz-Rode T, Moritz A, Dzemali O, Steinseifer U. The impact of aortic/subclavian outflow cannulation for cardiopulmonary bypass and cardiac support: a computational fluid dynamics study. Artif Organs., 2009; 33(9):727-32.
      • Hamilton KF, Schlanstein PC, Mager I, Schmitz-Rode T, Steinseifer U. Impact of hyperthermal rotary blood pump surfaces on blood clotting behavior: an approach. Artif Organs, 2009; 33(9):740-8.

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      Auszeichnungen

      • Willem J Kolff/Don B Olsen Award of the American Society of Artificial Internal Organs für das Manuskript "A 0-D/3-D Multiscale Multiphysics Approach to Computational Fluid Dynamics Studies Of Cardiopulmonary Bypass” für Michael Neidlin bei der 60. ASIAO Konferenz 2014; Washington, USA.

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      Vorträge

      Invited Talks

      2015

      • Sonntag SJ. Multi-Scale Multi-Physics Simulations for Cardiovascular Device Optimization. 33rd ANSYS Conference & CADFEM Users´ Meeting 2015, Bremen, Deutschland
      • Sonntag SJ, Kütting M, Zhonga Z, Vodiskar J, Vazquez-Jimenez J, Steinseifer U. Virtuelle Rekonstruktionen und 3D Druckverfahren für die Planung komplexer chirurgischer und interventioneller Eingriffe. Materialise seminar: 3D printing in hospitals 2015, Berg, Deutschland.

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      2013

      • Sonntag SJ, Kaufmann TAS, Büsen MR, Gräf F, Laumen M, Steinseifer U. Fluid-Structure-Interaction simulation of a pulsatile Total Artificial Heart: model development, validation and application. 1st International Workshop on Latest Advances in Cardiac Modeling 2013, München, Deutschland.

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      2012

      • Egger C. Pump Development. Masterclass – Hemodynamics in Extracorporeal Life Support, Maastricht University, Niederlande; 2012.

      • Sonntag SJ, Kaufmann TAS, Büsen MR, Gräf F, Laumen M, Steinseifer U. Fluid-Structure-Interaction Simulation of a pulsatile Total Artificial Heart. 30th ANSYS Conference & CADFEM Users´ Meeting 2012, Kassel, Deutschland.

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      Kongress-Vorträge

      2015

      • Egger C. The Impact of Ventricular Assist Device Implantation on the Acquired von Willebrand Syndrome – Comparison of Centrifugal and Axial Design. 44. Jahrestagung der Deutschen Gesellschaft für Thorax -, Herz - und Gefäßchirurgie 2015, Freiburg, Deutschland

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      2014

        • Egger C, Moza A, Maas J, Götzenich A, Autschbach R, Steinseifer U. Acquired von Willebrand Syndrome in VAD Patients: How fast does it occur? ISRBP 2014, San Francisco, USA.
        • Neidlin M, Steinseifer U. A 0-D/3-D Multiscale Multiphysics Approach to Computational Fluid Dynamics Studies Of Cardiopulmonary Bypass. 60th ASAIO 2014, Washington DC, USA.
        • Neidlin M, Steinseifer U. Multiscale Simulations of Aspiration Thrombectomy. XLI ESAO Konferenz 2014, Rom, Italien.
        • Neidlin M, Steinseifer U. Multiscale Simulations of Aspiration Thrombectomy. CMBBE 2014, Amsterdam, Niederlande.
        • Sonntag SJ, Wappenschmidt J, Goetzenich A, Steinseifer U, Autschbach R. Numerical simulation of a rotary piston type total artificial heart for the development of a novel drive and bearing concept. 41th ESAO meeting 2014, Rom, Italien.
        • Sonntag SJ, Li W, Becker M, Büsen MR, Marx N, Merhof D, Steinseifer U. Validation of a numerical approach to simulate color Doppler imaging of mitral regurgitation jets. 11th World Congress on Computational Mechanics XI 2014, Barcelona, Spanien.

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        2013

        • Egger C, Maas J, Hufen T, Steinseifer U. Acquired von Willebrand Syndrome (AvWS): A Lean and Sensitive Method to Investigate Design Parameters for Rotary Blood Pumps In Vitro. Gordon Research Conference 2013, Italien.
        • Egger C, Steinseifer U. Acquired von Willebrand Syndrome (AvWS): How to test devices in vitro. ESAO Conference 2013, Glasgow, Schottland.
        • Sonntag SJ, Kaufmann TAS, Büsen MR, Gräf F, Laumen M, Steinseifer U. Numerical washout study of a pulsatile Total Artificial Heart. 40th ESAO meeting 2013, Glasgow, Schottland.
        • Sonntag SJ, Li W, Becker M, Büsen MR, Marx N, Merhof D, Steinseifer U. Validation and further development of a novel numerical color Doppler reconstruction-based approach to improve heart valve regurgitation diagnosis. 40th ESAO meeting 2013, Glasgow, Schottland.
        • Sonntag SJ, Kaufmann TAS, Büsen MR, Gräf F, Laumen M, Steinseifer U. Two-phase Fluid-Structure-Interaction model for the investigation of chamber washout of a Total Artificial Heart. V International Symposium on Modelling of Physiological flows 2013, Chia Laguna, Sardinien, Italien.

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        2012

        • Sonntag SJ, Kaufmann TAS, Marco Laumen M, Linde T, Schmitz-Rode T, Steinseifer U. Simulation der Fluid-Struktur-Interaktion eines pulsatilen, totalen Kunstherzens. ANSYS Conference & 30. CADFEM Users´ Meeting 2012, Kassel, Germany.
        • Sonntag SJ, Kaufmann TAS, Marco Laumen M, Linde T, Schmitz-Rode T, Steinseifer U. Fluid structure interaction simulations of a total artificial heart: useful as a design tool? XXXIX. ESAO Konferenz 2012, Rostock, Germany.
        • Sonntag SJ, Kaufmann TAS, Marco Laumen M, Linde T, Schmitz-Rode T, Steinseifer U. Feasibility of Fluid Structure Interaction Simulations as a Design Tool of a Pulsatile Total Artificial Heart. 58th ASAIO conference 2012, San Francisco, USA.
        • Egger C, Maas J, Mager I, Schmitz-Rode T, Steinseifer U. Establishing of an In Vitro Method for Investigation of Mechanical Parameters causing Acquired von Willebrand Syndrome (AvWS) in VADs. ISRBP 2012, Istanbul, Türkei.

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        2011

        • Linde T, Candan S I, Schmitz-Rode T, Steinseifer U. Acustic Detection of Initial Thrombosis Formation in a Novel Heart Valve Test Rig. 37th ESAO conference 2011, Porto, Portugal.
        • Sonntag SJ. Large-Eddy Simulation Of Blood Flow Through Insufficient Mitral Valves Using A Localized Dynamic Kinetic Energy Model. Open Source CFD International Conference 2011, Paris-Chantilly, France.
        • Sonntag SJ. Numerical simulation of blood flow through insufficient mitral valves.  ECCOMAS Thematic International Conference on Simulation and Modeling of Biological Flows (SIMBIO 2011) , Brüssel, Belgien.

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        2010 und älter

        • Jansen SV, Behbahani M, Laumen M, Kaufmann T, Hormes M, Schmitz-Rode T, Behr M, Steinseifer U. 3D Stereo-PIV Validation for CFD Simulation of Steady Flow Through the Human Aorta Using Rapid-Prototyping Techniques. 2nd MPF Conference 2010, Chia Laguna, Italien.
        • Jansen SV, Behbahani M, Laumen M, Kaufmann T, Hormes M, Schmitz-Rode T, Behr M, Steinseifer U. Validation of CFD with PIV and other methods Part II. Young Researcher Initiative, 37th ESAO Conference 2010, Skopje, Mazedonien.
        • Linde T, Mager I, Cuenca Navalon E, Schmitz C, Utzerath M, Schmitz Rode T, Steinseifer U. Influence of the aortic root compliance on hemolysis and closing dynamics of heart valve prostheses: an in vitro study. 37th ESAO Conference 2010, Skopje, Mazedonien.
        • Egger C, Steinseifer U. Development of pneumatically-driven pump-lung for rescue applications. 2nd International Conference on Pediatric Mechanical Circulatory Support Systems and Cardiopulmonary Perfusion 2006, Toronto, Ontario, Kanada.

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        Poster

        2015

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        2014

        • Büsen M, Kaufmann TAS, Neidlin M, Jansen SV, Steinseifer U. 3D-Flow investigations in the aortic arch during cardiopulmonary bypass with Stereo-PIV. ASAIO Konferenz 2014, Washington, USA.
        • Büsen M, Graefe R, Amaral F, Jansen SV, Steinseifer U. PIV flow investigations in a rotary blood pump for specific blade positions. ESAO Konferenz 2014, Rom, Italien.
        • Egger C, Wölke E, Götzenich A, Steinseifer U. Development of In Vitro Diagnostics to Investigate Acquired von Willebrand Syndrome caused by ECLS-Devices and Artificial Lung. I³TM Symposium 2014, Aachen, Deutschland.

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        2013

        • Sonntag SJ. Combined computational and experimental approach to improve the assessment of mitral regurgitation. International Conference for Innovations 2013, Tel-Aviv, Israel.

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        2012

        • Sonntag SJ, Kaufmann TAS, Marco Laumen M, Linde T, Schmitz-Rode T, Steinseifer U. Fully coupled 3D Fluid-Structure-Interaction Simulations of a Total Artificial Heart. Computational Fluid Dynamics (CFD) in Medicine and Biology in conjunction with the 7th International Biofluid Mechanics Symposium 2012, Dead Sea, Israel.
        • Sonntag SJ, Kaufmann TAS, Linde T, Schmitz-Rode T, Steinseifer U. Feasibility of fluid structure interaction simulations as a design tool of a total artificial heart. CFD in Medicine and Biology – ECI 2012, Ein Bokek, Israel.

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        2011 und älter

        • Linde T, Famaey N, Schmitz-Rode, Steinseifer U, Meuris B. Asynchrony of disc impacts in Bileaflet Heart Valve Closure Depends on Pressure and Pulse Rate. 35th ESAO Conference 2009, Compiègne, France.

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        Patente

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        Gruppenleitung

        Dr. Ing. Jutta Arens

        Tel.: +49 241 80 87018

        E-Mail