Sabine Koch
Tätigkeitsgebiete:
- Synthese und Kutivierung von tissue engineerten Gefäßprothesen aus ovinen Zellen zur späteren autologen Implantation
- Histologische sowie immunhistologische Analyse des tissue engineerten Gewebes
- Zellkultur autologer Zelllinien
Werdegang im Bereich Tissue Engineering
Juli 2001 - März 2004
Gesteuerte Vaskularisierung von ungerichtet erstarrten Matrices aus Kollagen durch Inkorporierung angiogenetischer Faktoren
Institut für Biochemie, RWTH Aachen
seit April 2004
Kardiovaskuläres Tissue Engineering: Entwicklung von kleinlumigen Gefäßprothesen aus körpereigenem Gewebe
Intelligent Biomaterial Systems for Cardiovascular Tissue Repair
Lehrstuhl für Angewandte Medizintechnik (AME), Helmholtz Institut, RWTH Aachen
Publikationen
Koch S, Stappenbeck N, Cornelissen C, Flanagan TC, Mela P, Sachweh J, Hermanns-Sachweh B, Jockenhoevel S. Tissue Engineering - selecting the optimal fixative for immunohistochemistry, Tissue Eng Part C Methods. 2012 Jun 14, Epub. Pubmed.
Koch S, Flanagan TC, Sachweh JS, Tanios F, Schnoering H, Deichmann T, Ellä V, Kellomäki M, Gronloh N, Gries T, Tolba R, Schmitz-Rode T, Jockenhoevel S. Fibrin-polylactide-based tissue-engineered vascular graft in the arterial circulation, Biomaterials. 2010 Jun;31(17):4731-9. Epub 2010 Mar 20.
Flanagan TC, Sachweh JS, Frese J, Schnöring H, Gronloh N, Koch S, Tolba RH, Schmitz-Rode T, Jockenhoevel S. In vivo remodeling and structural characterization of fibrin-based tissue-engineered heart valves in the adult sheep model. Tissue Eng Part A. 2009 Oct;15(10):2965-76.
Tschoeke B, Flanagan TC, Koch S, Harwoko MS, Deichmann T, Ellå V, Sachweh JS, Kellomåki M, Gries T, Schmitz-Rode T, Jockenhoevel S. Tissue-engineered small-caliber vascular graft based on a novel biodegradable composite fibrin-polylactide scaffold. Tissue Eng Part A. 2009 Aug;15(8):1909-18.
Tschoeke B, Flanagan TC, Cornelissen A, Koch S, Roehl A, Sriharwoko M, Sachweh JS, Gries T, Schmitz-Rode T, Jockenhoevel S. Development of a composite degradable/nondegradable tissue-engineered vascular graft. Artif Organs. 2008 Oct;32(10):800-9. Epub 2008 Jul 21.
Flanagan TC, Cornelissen C, Koch S, Tschoeke B, Sachweh JS, Schmitz-Rode T, Jockenhoevel S. The in vitro development of autologous fibrin-based tissue-engineered heart valves through optimised dynamic conditioning. Biomaterials. 2007 Aug;28(23):3388-97. Epub 2007 Apr 13.
Koch S, Yao Ch, Grieb G, Prével P, Noah E. M. , Steffens G. C. M. (2006) Enhancing angiogenesis in collagen matrices by covalent incorporation of VEGF. J Mater Sci: Mater Med (2006) 17: 735-741
Yao C, Prével P, Koch S, Schenck P, Noah EM, Pallua N, Steffens G., Modification of collagen matrices for enhancing angiogenesis, Cells Tissues Organs. 2004; 178(4):189-96.
Proceedings
Flanangan TC, Cornelissen C, Koch S, Tschoeke B, Sachweh JS, Schmitz-Rode T, Jockenhoevel S. Matruration of Fibrin-Based Tissue Engineered Heart Valves in Vitro Using a Customised Bioreactor System. Biomedizinische Technik 2007 (52) Proceedings CD printed
Veggian P, Sachweh JS, Koch S, Tschoeke B, Schmitz-Rode T, Jockenhoevel S. Erste Erfahrungen in der ex vivo Kultivierung pericardialer Patchstrukturen. Biomedizinische Technik 2006 (51) Proceedings CD printed
Flanagan TC, Frese J, Sachweh JS, Diamantouros S, Koch S, Schmitz-Rode T, Jockenhoevel S. The Use of Fibrin as an Autologous Scaffold Material for Cardiovascular Tissue Engineering Applications: From In Vitro to In Vivo Evaluation. In Vander Sloten J, VerdonckR, Nyssen M, Haueisen J (Eds.) IFMBE Proceedings, Springer Verlag Berlin, Heidelberg New York 2008 (22(ISSN 1680-0737/ISBN 978-3-540-89207-6)): 2186-2190
Abstracts/Conference Publications
Flanagan TC, Frse J, Diamantouros S, Koch S, Schmitz-Rode T, Jockenhoevel S, The Use of Fibrin as an Autologous Scaffold Mateerial for Cardiovascular Tissue Engineering Applications: From In Vitro to In Vivo Evaluation IFMBE Antwer 2008
Veggian P, Flanagan TC, Hesse B, Sachweh JS, Koch S, Schmitz-Rode T, Jockenhoevel S. Ex Vivo expansion of autologous pericardial patch structures. Thorac cardiovasc Surg 2008; 56 Suppl.
Veggian P, Flanagan TC, Hesse B, Sachweh JS, Koch S, Schmitz-Rode T, Jockenhoevel S. Ex vivo expansion of autologous pericardial patch structures. Thorac cardiovasc Surg 2008; 56 Suppl.
Flanagan TC, Cornelissen C, Koch S, Tschoeke B, Sachweh JS, Schmitz-Rode T, Jockehoevel S. Enhanced tissue development in autologus tissue-engineered heart valves using a customised bioreactor conditioning system. Thorac. Crdiovasc Surg 2008; 56 Suppl.
Tschoeke B, Flanagan TC, Sri Harwoko M, Deichmann T, Ellä V, Koch S, Glitz A, Schmitz-Rode T, Gries T, Kellomäki M, Jockenhoevel S. Tissue Engineering of small calibre vascular grafts using a novel fibrin-polylactid acid composite scaffold. Thorac Cardiovasc Surg 2008; 56 Suppl.
Flanagan TC, Cornelissen C, Koch S, Tschoeke B, Sachweh JS, Schmitz-Rode T, Jockenhoevel S. Optimised Dynamic Conditioning Enhances in Vitro Development of Autologous Fibrin-Based Tissue Engineered Heart Valves. Tissue Engineering 2007; 13(7):1738
Tschoeke B Sri Harwoko M, Ellä V, Koch S, Glitz A, Schmitz-Rode T, Gries T, Kellomäki M, Jockenhoevel S. Tissue Engineering of Small Calibre Vascular Grafts. Tissue Engineered Heart Valves. Tissue Engineering 2007; 13(7):1770
Veggian P, Sachweh JS, Flanagan TC, Koch S, Tschoeke B, Schmitz-Rode T, Jockenhoevel S. Ex vivo Expansion of Pericardial Patch Structures. Tissue Engineered Heart Valves. Tissue Engineering 2007; 13(7):1775
Glitz A, Koch S, Sri Harwoko M, Tschoeke B, Gries T, Jockenhoevel S. Cardiovascular Tissue Engineering: Vascular Composite Graft. Biomedica 2007, Aachen, Abstractbook 13
Veggian P, Sachweh JS, Koch S, Tschoeke B, Flanagan TC, Schmitz-Rode T, Jockenhoevel S. Ex vivo Expansion of Pericardial Patch Structures. Biomedica 2007, Aachen, Abstractbook 11
