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Development of a Percutaneously Implantable Heart Valve Prosthesis

Percutaneous Valve (FEM Simulation)

In this project, a percutaneously (through the skin) implantable heart valve prosthesis made from biocompatible Polyurethane shall be developed for the pulmonary position. By use of polyurethane the outer diameter of the application catheter may be substantially reduced. The valved stent may therefore be used for children as well, and further surgeries may be postponed to the benefit of the patient.


Project Goal

The project goal is the design and development of an artificial heart valve for percutaneous implantation in the pulmonary position, which



  • provides optimal flow patterns,
  • is made from biocompatible material,
  • does not require life long anticoagulation therapy,
  • is durable,
  • provides a strong and durable attachment of the polymer leaflets to the stent struts (preferably Nitinol),
  • withstands even increased pulmonary pressures,
  • functions sufficiently after compression and expansion,
  • is available in small diameters,
  • is applicable via a small device (target: << 18 F (6 mm)).


First of all a valved stent shall be designed, manufactured and tested. Comprehensive design studies and numerical simulations (see Fig. 1) will be performed in order to assure optimal designs of valve and stent. The numerical simulations will be validated by experimental studies on lab prototypes, before functional studies will be performed in a large animal model (sheep).


Dipl.-Ing. Ute Urban

Tel.: +49 241 80 80568



This project is sponsored by:


Student Theses

For student theses click here.