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Publications of the Artificial Lung Group

Books

  • Borchardt R: Einfluss intern erzeugter, pulsierender Strömung auf Gas- und Wärmeaustausch in einem Membranoxygenator. Aachener Beiträge zur Medizintechnik, Band 29. ISBN: 978-3-8440-3678-7. Shaker-Verlag. 2015
  • Arens J: Konzeptionierung, Entwicklung und Validierung einer miniaturisierten Herz-Lungen-Maschine für Neugeborene mit angeborenem Herzfehler. Aachener Beiträge zur Medizintechnik, Band 19. ISBN: 978-3-8440-2297-1. Shaker-Verlag. 2013
  • Hormes M: CFD-basierte Modellbildung und Validierung des Gastransfers zur Analyse der Blutoxygenierung über Hohlfasermembranen. Aachener Beiträge zur Medizintechnik, Band 6. ISBN: 978-3-8440-0062-7. Shaker-Verlag. 2011
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Journal Articles

    2016

  • Kaesler A, Schlanstein PC, Hesselmann F, Büsen M, Klaas M, Roggenkamp D, Schmitz-Rode T, Steinseifer U, Arens J: Experimental approach to visualize flow in a stacked hollow fiber bundle of an artificial lung with particle image velocimetry. Artificial Organs, epublished ahead of print, Nov 2016.
  • Bleilevens C, Grottke O, Groening S, Honickel M, Kopp K, Singh S, Arens J, Rossaint R: Septic porcine blood does not further activate coagulation during in vitro membrane oxygenation. European Journal of Cardio-Thoracic Surgery, page ezw345, Nov 2016.
  • Wagner G, Kaesler A, Schmitz-Rode T, Steinseifer U, Arens J: Comment on “The promise of microfluidic artificial lungs” by J. A. Potkay, Lab Chip, 2014, 14, 4122-4138. Lab Chip, DOI: 10.1039/C5LC01508A, 2016
  • Kopp R, Bensberg R, Stollenwerk A, Arens J, Grottke O, Walter M, Rossaint R: Automatic Control of Veno-Venous Extracorporeal Lung Assist. Artif Organs, epublished ahead of print, 2016
  • Cornelissen C, Finocchiaro N, Arens J, Dreher M, Jockenhövel S: Leistungstest eines biohybriden Lungenunterstützungssystem. Pneumologie, Thieme Publishing Group, 70, 2016

    2015

  • Dietrich M, Finocchiaro N, Olszweski S, Arens J, Schmitz-Rode T, Sachweh J, Jockenhoevel S, Cornelissen CG: ENDOXY - Development of a Biomimetic Oxygenator-Test-Device. PLoS One, 10, e0142961, 2015
  • Bleilevens C, Grottke O, Tillmann S, Honickel M, Kopp R, Arens J, Rossaint R: 12 hours in vitro biocompatibility testing of membrane oxygenators. ASAIO Journal, e-published ahead of print, 2015
  • Stang K, Borchardt R, Neumann B, Kurz J, Stoppelkamp S, Greiner TO, Farner C, Schenk M, Schlensak C, Schubert M, Lausberg H, Herold S, Schlanstein PC, Steinseifer U, Arens J, Wendel HP: First in-vivo results of a novel pediatric oxygenator with an integrated pulsatile pump. ASAIO Journal, e-published ahead of print, 2015
  • Schlanstein PC, Hesselmann F, Jansen SV, Gemsa J, Kaufmann TA, Klaas M, Roggenkamp D, Schröder W, Schmitz-Rode T, Steinseifer U, and Arens J. Particle image velocimetry used to qualitatively validate computational fluid dynamic simulations in an oxygenator: A proof of concept. Cardiovascular Engineering and Technology, pages 1–12, 2015
  • De Brouwer P, Mager I, Kopp R, Walter M, Stollenwerk A, Schmitz-Rode T, Steinseifer U, Arens J: Dynamische Studie zum Einfluss von negativem Druck auf Hämolyse. Kardiotechnik, 24(1):3–6, 2015
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    2014

  • Kaesler A, Wagner G, Steinseifer U, Arens J: Kliniknahe Forschung an Hohlfasermembranoxygenatoren. Kardiotechnik, 23(4):109–113, 2014
  • Kaufmann TAS, Schlanstein P, Moritz A, Steinseifer U: Development of a hemodynamically optimized outflow cannula for cardiopulmonary bypass. Artif Organs, 38(11):972–978, 2014
  • Fiehe S, Wagner G, Schlanstein P, Rosefort C, Kopp R, Bensberg R, Knipp P, Schmitz-Rode T, Steinseifer U, Arens J: Implementation of quality management in early stages of research and development projects at a University. Biomedizinische Technik/Biomedical Engineering. 59(2):135–145, 2014
  • Wagner G, Schlanstein P, Fiehe S, Kaufmann T, Kopp R, Bensberg R, Schmitz-Rode T, Steinseifer U, Arens J: A novel approach in extracorporeal circulation: individual, integrated, and interactive heart-lung assist (I3-Assist). Biomedizinische Technik/Biomedical Engineering. 59(2):125–133, 2014
  • Cornelissen CG, Engwicht S, Arens J, and Jockenhoevel S: Biohybride Lungenunterstützungssysteme. Pneumologie, 68(S 01):V582, 2014
  • Schoberer M, Arens J, Erben A, Ophelders D, Jellema RK, Kramer BW, Bruse JL, De Brouwer P, Schmitz-Rode T, Steinseifer U, Orlikowsky T: Minaturization: The Clue to Clinical Application of the Artificial Placenta. Artif Organs. 38(3):208–214, 2014
  • Schlanstein PC, Borchardt R, Mager I, Schmitz-Rode T, Steinseifer U, Arens J: Gas exchange efficiency of an oxygenator with integrated pulsatile displacement blood pump for neonatal patients. Int J Artif Organs. 1(37): 88–92, 2014
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    2013

  • Schlanstein PC, Arens J, Borchardt R, Hesselmann F, Jansen SV, Schmitz-Rode T, Steinseifer U, Wagner G: Oxygenator Flow Pattern: PIV of a Fiber Oxygenator. International Journal of Artificial Organs, 36(8):554, 2013
  • Schnoering H, Arens J, Detering SM, Sachweh JS, Goetzenich A, Schmitz-Rode T, Steinseifer U, Vazquez-Jimenez JF: Expression of Inflammation in Myocardial Tissue of Rabbits: Comparison of Two Miniaturized Heart-Lung Machines. Artif Organs, 37(6):541–548, 2013
  • Borchardt R, Schlanstein P, Mager I, Arens J, Schmitz-Rode T, Steinseifer U. In-vitro-Testung eines Oxygenators mit integrierter pulsatiler Pumpe für pädiatrische Anwendungen. Kardiotechnik. 22(2): 36–42, 2013
  • Schnoering H, Arens J, Detering SM, Stopinski T, Kuschel TJ, Tolba R, Steinseifer U, Vazquez-Jimenez JF: Development of a rabbit animal model for miniaturized heart-lung machines. ASAIO Journal, 59(2):152–156, 2013
  • Walter M, Brendle C, Stollenwerk A, Kopp R, Arens J, Bensberg R, Leonhardt S: Patient oriented closed loop control of extracorporeal lung assist. Journal of Critical Care. 28(1):e8–e9, 2013
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    2012

  • Arens J, Schnoering H, De Brouwer P, Pfennig M, Mager I, Vazquez-Jimenez JF, Schmitz-Rode T, Steinseifer U: Die Aachener MiniHLM – Eine miniaturisierte Herz-Lungen-Maschine für Neugeborene mit angeborenem Herzfehler. Kardiotechnik, 21(4):91-96, Dezember 2012

  • Borchardt R, Schlanstein P, Mager I, Arens J, Schmitz-Rode T, Steinseifer U: In Vitro Performance Testing of a Pediatric Oxygenator With an Integrated Pulsatile Pump ASAIO Journal. 58(4):420-425, July/August 2012

  • Schoberer M, Arens J, Lohr A, Seehase M, Jellema RK, Collins JJ, Kramer BW, Schmitz-Rode T, Steinseifer U, and Orlikowsky T: Fifty years of work on the artificial placenta: Milestones in the history of extracorporeal support of the premature newborn. Artif Organs, 36(6):512-516, 2012.

  • Arens J, Schoberer M, Erben A, Orlikowsky T, Ophelders D, Jellema RK, Kramer BW, De Brouwer P, Schmitz-Rode T, Steinseifer U: Neonatox: A Pumpless Extracorporeal Lung Support for Premature Infants. ASAIO J, 58(7):48, 2012

  • Borchardt R, Schlanstein PC, Arens J, Mager I, Schmitz-Rode T, Steinseifer U: Development of a pediatric oxygenator with integrated pulsatile pump and heat exchanger. ASAIO J, 58(7):48, 2012

  • Arens J, Schoberer M, Erben A, Orlikowsky T, Ophelders D, Jellema RK, Kramer BW, De Brouwer P, Schmitz-Rode T, Steinseifer U: The NeonatOx: An Update on Design, In-Vitro, and In-Vivo Testing. Artif Organs, 36(5):A23, 2012

  • Schoberer M, Arens J, Erben A, Ophelders D, Jellema RK, Kramer BW, De Brouwer P, Schmitz-Rode T, Steinseifer U, Orlikowsky T: Miniaturisation: The Clue to Clinical Application of the Artificial Placenta. Artif Organs, 36(5):A24, 2012

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    2011

  • Arens J, Schoberer M, Lohr A, Orlikowsky T, Seehase M, Jellema RK, Collins JJ, Kramer BW, Schmitz-Rode T, Steinseifer U: NeonatOx - A Pumpless Extracorporeal Lung Support for Premature Neonates. Artificial Organs. 35(11):997-1001, 2011
  • Arens J, Schoberer M, Lohr A, Orlikowsky T, Seehase M, Jellema RK, Collins JJ, Kramer BW, Schmitz-Rode T, Steinseifer U: A Pumpless Extracorporeal Lung Assist for Premature Neonates: The Aachen Neonatox. Int J Artif Organs. 34(8): 670, 2011
  • Schlanstein PC, Wagner G, Arens J, Pedraza D, Kopp R, Bensberg R, Rossaint R, Schmitz-Rode T, Steinseifer U:  Heart Lung Machine and Extracorporeal Life Support: A Modular System. Int J Artif Organs. 34(8): 625, 2011
  • Walter M, Brendle C, Arens J, Stollenwerk A, Kopp R, Bensberg R, Leonhardt S: Physiological Target Control in Long-Term Extracorporeal Oxygenation. Int J Artif Organs. 34(8): 625, 2011
  • Borchardt R, Schlanstein P, Mager I, Arens J, Schmitz-Rode T, Steinseifer U: Experimental and Numerical Results of a Neonatal Oxygenator with Integrated Pulsatile Pump and Heat Exchanger. Int J Artif Organs. 34(8): 624, 2011
  • Stollenwerk A, Gathmann F, Arens J, Bensberg R, Walter M, Kopp R, Kowalewski S: Safety Aware Pump-Control for a Rotary ECMO Blood Pump. Int J Artif Organs. 34(8): 617, 2011
  • Borchardt, R, Schlanstein, P, Mager, I, Arens, J, Schmitz-Rode, T, Steinseifer, U: Experimental and numerical results of a neonatal oxygenator with integrated pulsatile pump and heat exchanger. Biomed Tech. 56 (Suppl. 1) 2011
  • Wagner, G, Schlanstein, P, Arens, J, Kopp, R, Bensberg, R, Rossaint, R, Schmitz-Rode, T, Steinseifer, U: Consolidation of HLM and ECLS - The Modular Concept of I3-Assist. Biomed Tech. 56 (Suppl. 1) 2011
  • Brendle, C; Bensberg, R; Stollenwerk, A; Arens, J; Walter, M:  Patient orientated automation of the therapy with the Extracorporeal Membrane Oxygenation (ECMO). Biomed Tech.  56 (Suppl. 1) 2011
  • Arens, J; Schoberer, M; Lohr, A; Orlikowsky, T. Seehase, M; Jellema, R; Collins, JJ; Kramer, BW; Schmitz-Rode, T; Steinseifer, U: Developing a Pumpless Extracorporeal Lung Support for Premature Neonates (NeonatOx). Biomed Tech. 56 (Suppl. 1) 2011

  • Arens J, Schoberer M, Lohr A, Orlikowsky T, Seehase M, Jellema RK, Collins JJ, Kramer BW, Schmitz-Rode T, Steinseifer U: NeonatOx - A Pumpless Extracorporeal Lung Support for Premature Neonates. Artificial Organs. 35(4):A8, 2011
  • Schoberer M, Arens J, Lohr A, Seehase M, Jellema RK, Collins JJ, Kramer BW, Schmitz-Rode T, Steinseifer U, Orlikowsky T: 50 Years of Research on the Artificial Placenta: Can we turn a Toy into a Treasure? Artificial Organs. 35(4):A9, 2011
  • Wagner G, Schlanstein P, Arens J, Kopp R, Bensberg R, Rossaint R, Schmitz-Rode T, Steinseifer U: I³-Assist: Individual, Interactive, and Integrated Cardiopulmonary Assist - A Concept. Artificial Organs. 35(4):A9, 2011
  • Borchardt R; Schlanstein P; Mager I; Arens J; Schmitz-Rode T; Steinseifer U: Experimental Evaluation of an Oxygenator With Integrated Pulsatile Pump for Pediatric Applications. Artificial Organs. 35(4): A17, 2011
  • Bhavsar S; Seiwert M; Borchardt R; Graefe R; Schlanstein P; Arens J; Schmitz-Rode T; Steinseifer U: Numerical Modeling of Anisotropic Fiber Bundle Behavior in Oxygenators. Artificial Organs. 35(4): A18, 2011
  • Borchardt R; Hormes M; Schmitz Rode T; Steinseifer U: Numerical Investigation of the Influence of Pulsatile Flow on Gas Exchange Inside an Oxygenator. Artificial Organs. 35(4): A21, 2011
  • Kopp R, Bensberg R, Arens J, Steinseifer U, Schmitz-Rode T, Rossaint R, Henzler D: A Miniaturized Extracorporeal Membrane Oxygenator with Integrated Rotary Blood Pump: Preclinical In Vivo Testing. ASAIO Journal. 57(3): 158-163, 2011
  • Borchardt R; Schlanstein P; Mager I; Arens J; Schmitz-Rode T; Steinseifer U: In-vitro performance testing of a pediatric oxygenator with integrated pulsatile pump. ASAIO Journal. 57(2): 109, 2011
  • Hormes M; Borchardt R; Mager I; Schmitz Rode T; Behr M; Steinseifer U: A validated CFD model to predict O2 and CO2 transfer within hollow fiber membrane oxygenators. Int J Artif Organs. 34(3): 317-325, 2011
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      2010

    • Graefe R; Borchardt R; Arens J; Schlanstein P; Schmitz-Rode T; Steinseifer U: Improving oxygenator performance using computational simulation and flow field-based parameters. Artif Organs. 34(11):930-936, 2010
    • Schnoering H; Arens J; Terrada E; Sachweh JS; Runge M; Schmitz-Rode T; Steinseifer U; Vazquez-Jimenez JF:  A newly developed miniaturized heart-lung machine – expression of inflammation in a small animal model. Artificial organs. 34(11):911-917, 2010
    • Borchardt R, Schlanstein P, Arens J, Graefe R, Schreiber F, Schmitz-Rode T, et al. Description of a flow optimized oxygenator with integrated pulsatile pump. Artificial Organs. 34(11):904–910, 2010
    • Arens J; Schnoering H; Pfennig M; Mager I; Vázquez-Jiménez JF; Schmitz-Rode T; Steinseifer U: The Aachen MiniHLM – A Miniaturized Heart-Lung Machine for Neonates with an Integrated Rotary Blood Pump. Artificial organs. 34(9):707-713, 2010
    • A. Stollenwerk, J. Jörgens, J. Arens, M. Walter, R. Kopp, and S. Kowalewski: Model Based Diagnosis for Extracorporeal Membrane Oxygenation. The International Journal of Artificial Organs, vol. 33, iss. 7, p. 447, 2010
    • Schlanstein PC, Borchardt R, Arens J, Schmitz-Rode T, Steinseifer U: Investigation of the influence of pulsating silicone tubes inside an oxygenator. The International Journal of Artificial Organs, vol. 33, iss. 7, p. 423, 2010
    • Arens J, De Brouwer P, Mager I, Brücker C, Schäfer M, Jacobs P, Schmitz-Rode T, Steinseifer U: Hemocompatibility Tests on Materials for a Multi-Tactile Sensor Concept. The International Journal of Artificial Organs, vol. 33, iss. 7, p. 480, 2010
    • Walter, M.; Weyer, S.; Stollenwerk, A.; Kopp, R.; Arens, J., Leonhardt, S.: A physiological model for extracorporeal oxygenation controller design. Conf Proc IEEE Eng Med Biol Soc, 1, 434-437, 2010
    • A. Stollenwerk, J. Jörgens, M. Walter, J. Arens, R. Kopp, and S. Kowalewski: Modelbasierte Fehlerdiagnose eines Membranoxygenators, in Proc. Biomedizinische Technik (BMT2010), 2010, vol. 55, de Gruyter, pp. 174-177
    • M. Walter, A. Stollenwerk, T. Wartzek, J. Arens, R. Kopp, and S. Leonhardt: Automatisierung und Fehlerdiagnose bei der extrakorporalen Membranoxygenierung. at – Automatisierungstechnik, vol. 58, iss. 5, pp. 277-285, 2010
    • J. Arens, P. De Brouwer, I. Mager, R. Kopp, M. Walter, A. Stollenwerk, T. Schmitz-Rode, and U. Steinseifer: A Dynamic Study on the Hemolytic Effect of Negative Pressure on Blood. ASAIO journal, vol. 56, iss. 2, pp. 96-96, 2010
    • Hormes M., Borchardt R., Schmitz-Rode T., Behr M., Steinseifer U. Pulsatile versus non pulsatile blood flow in blood oxygenators: a CFD study. ASAIO Journal. 56(2): 107, 2010
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      2009

    • Heike Schnoering, Jutta Arens, Joerg S. Sachweh, Melanie Veerman, Rene Tolba, Thomas Schmitz-Rode, Ulrich Steinseifer, and Jaime F. Vazquez-Jimenez: The Aachen Miniaturized Heart-Lung Machine – First Results in a Small Animal Model. Artificial Organs. 33(11):935–940,2009
    • J. Arens, H. Schnöring, M. Pfennig, I. Mager, J. Vázquez-Jiménez, T. Schmitz-Rode, and U. Steinseifer: The Aachen MiniHLM – A Miniaturized Heart Lung Machine for Neonates with Congenital Heart Defect. In: O. Dossel and W.C. Schlegel (Eds.): WC 2009 IFMBE Proceedings 25/VII; pp. 373-376, 2009
    • Rüdger Kopp, Marian Walter, Jutta Arens, André Stollenwerk, Steffen Leonhardt, Thomas Schmitz-Rode, Stefan Kowalewski, Rolf Rossaint: Regelungs- und Sicherheitskonzepte für extrakorporale Systeme zur Lungenunterstützung / Automatic control and safety concepts for extracorporeal lung support. Biomedizinische Technik/Biomedical Engineering. Band 54, Heft 5, Seiten 289–297, 2009
    • Hormes M., Borchardt R., Behr M., Schmitz-Rode T., Steinseifer U. A Validated CFD Model to Predict O2 and CO2 Transfer within Hollow Fiber Membrane Oxygenators. Int J Artif Organs. 2009;32(7):400–401
    • A. Stollenwerk, M. Walter, T. Wartzek, R. Kopp, J. Arens, and S. Kowalewski, "A Safety and Control Concept for Extracorporeal Membrane Oxygenation", The International Journal of Artificial Organs, vol. 32, iss. 7, p. 428, 2009
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      – 2008

    • Arens J.; Schnöring H.; Reisch F..; Vázquez-Jiménez JF.; Schmitz-Rode T.; Steinseifer U.: Development of a Miniaturized Heart-Lung Machine for Neonates With Congenital Heart Defect. ASAIO Journal. 54(5):509-513, 2008
    • Hormes M., Kashefi A., Borchardt R., Schmitz-Rode T., Steinseifer U. CFD Simulation Of Oxygen Transfer In Hollow Fiber Oxygenators. Int J Artif Organs. 2008;31(7):641–641
    • Hormes M., Kashefi A., Borchardt R., Schmitz-Rode T., Steinseifer U. A Numerical Model of Oxygen Transfer in Hollow Fiber Oxygenators. ASAIO Journal. 54(2): 63A, 2008
    • J. Arens, H. Schnöring, B. Buding, J. Vazquez, T. Schmitz-Rode, U. Steinseifer: Entwicklung einer miniaturisierten Herz-Lungen-Maschine für Neugeborene mit angeborenem Herzfehler.  41. Jahrestagung der Deutschen Gesellschaft für Biomedizinische Technik im VDE, Vol. 52, 2007, ISSN 0939-4990
    • Cattaneo, G. F. M.; Reul, H.; Schmitz-Rode, T. & Steinseifer, U.: Intravascular blood oxygenation using hollow fibers in a disk-shaped configuration: experimental evaluation of the relationship between porosity and performance.
      ASAIO Journal, 52():180-185 2006
    • Cattaneo, G. F. & Reul, H.: New fiber configuration for intravenous gas exchange.
      The International Journal of Artificial Organs, vol. 28, p 244-250, 2005
    • A. Strauß, G. Cattaneo, J. Arens, H. Reul, U. Steinseifer, T. Schmitz-Rode: Development of a Highly Integrated Extracorporeal Membrane Oxygenator with Rotary Blood Pump – Concept and Functionality. Biomedizinische Technik, Volume 50, Suppl. Vol. 1, Part 2, 2005
    • Cattaneo, G.; Strauss, A. & Reul, H.: Compact intra- and extracorporeal oxygenator developments. Perfusion, 19, p 251-255, 2004
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    Awards

    • Biomedical Engineering Award based on the manuscript "I³-Assist: Individual, Interactive, and Integrated Cardiopulmonary Assist - A Concept" to Georg Wagner at the 7th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion, May 05-07, 2011; Philadelphia, PA, USA
    • John A. Waldhausen Young Investigator Award based on the manuscript "NeonatOx – A pumpless Extracorporeal Lung Support for Premature Neonates" to Jutta Arens at the 7th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion, May 05-07, 2011; Philadelphia, PA, USA
    • William S. Pierce, MD Young Investigator Award based on the manuscript “The Aachen MiniHLM–first results in a small animal model” to Heike Schnöring, MD, at the 5th International Conference on Pediatric Mechanical Circulatory Support Systems and Cardiopulmonary Perfusion, May 27–30, 2009; Dallas, Texas, USA
    • AKM Förderpreis 2008, 2. Platz an Jutta Arens für das Projekt "Development of a Miniaturized Heart-Lung Machine for Neonates with Congenital Heart Defect"
    • Helmut Reul, PhD, Young Investigator Award based on the manuscript "Development of a Miniaturized Heart-Lung Machine for Neonates with Congenital Heart Defect" to Jutta Arens at the 4th International Conference on Pediatric Mechanical Circulatory Support Systems and Cardiopulmonary Perfusion, May 22–24, 2008; Portland, Oregon, USA

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    Presentations

    Invited Talks

      2015

    • Arens J: News on Pumps ‒ Is Blood Trauma avoidable? EuroELSO 2015 - 4th International Congress, Regensburg, Germany, May 2015

      2014

    • Arens J: Die Zukunft der Herz-Chirurgie ... aus Sicht einer Forscherin
      43. Internationale Jahrestagung und 6. Fokustagung Herz der DGfK und DGTHG, Nürnberg, Germany, November, 2014

    • Arens J: Verbesserung der Biokompatibilität von ECMO-Systemen
      Herbsttagung der Sektion Intensiv- und Beatmungsmedizin der DGP und der Sektion Pneumologie der DGIIN, Köln, Germany, November, 2014

    • Arens J: Development of a Miniaturized Heart-Lung Machine for Neonates.
      ASAIO 60th Annual Conference, Washington, DC, USA, June, 2014

      2013

    • Arens J: Oxygenator Development at The Helmholtz Institute Aachen: Past, Present, and Future.
      ASAIO 59th Annual Conference, Chicago, IL, USA, June, 2013

      2012

    • Arens J: Extracorporeal lung support in the preterm infant.
      3rd International Pediatric Perfusion Symposium, Toronto, Canada, October 2012

    • Borchardt R: Lung: Understanding organ function and treatment options for dysfunction.
      4th YoungESAO Conference, Rostock, September 2012

    • Arens J, Schoberer M: Extracorporeal Lung support in the preterm infant.
      XI Update on Neonatology, Florence, Italy, May 2012

      2011

    • Arens J: Miniaturization of Extracorporeal Blood Circuits: Concepts and Solutions.
      2nd International Pediatric Perfusion Symposium, October 2011; Dubai, UAE

      2008

    • Schnöring H; Arens J: Entwicklung einer miniaturisierten Herz-Lungen-Maschine – MiniHLM.
      18. Terumo Technologie Seminar, November 2008, Freiburg

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    Congress Presentations

      2014

    • Hesselmann F, Schlanstein PC, Jansen SV, Schmitz-Rode T, Steinseifer U, Arens J: Flow in a Cross Layer Fiber Oxygenator: Validation of Computational Fluid Dynamics using Particle Image Velocimetry.
      Slide presentation at the XLI. Annual ESAO Congress (European Society for Artificial Organs), Sep 2014

    • Borchardt R, Schlanstein P, Mager I, Schmitz-Rode2 T, Steinseifer U, Arens J. Oxygenator With Integrated Pulsatile Pump And Heat Exchanger: In-Vitro and In-Vivo Results.
      Slide presentation at the 60th Annual Conference of ASAIO (American Society of Artificial Internal Organs), Washington, June 2014

    • Borchardt R, Schlanstein P, Mager I, Schmitz-Rode2 T, Steinseifer U, Arens J. Investigating Effects of Internal Pulsation on Gas & Heat Exchange in an Oxygenator.
      Slide presentation at the 60th Annual Conference of ASAIO (American Society of Artificial Internal Organs), Washington, June 2014

    • Schlanstein PC, Hesselmann F, Jansen SV, Schmitz-Rode T, Steinseifer U, Arens J. Particle Image Velocimetry for the Validation of Computational Fluid Dynamic Simulations of a Cross Layered Oxygenator.
      Slide presentation at the 60th Annual Conference of ASAIO (American Society of Artificial Internal Organs), Washington, June 2014

      2013

    • Hesselmann F, Schlanstein PC, Wagner G, Borchardt R, Jansen SV, Schmitz-Rode T, Steinseifer U, Arens J: Oxygenator flow pattern: PIV of a fiber membrane Oxygenator.
      Slide presentation at the XXXX. Annual ESAO Congress (European Society for Artificial Organs), Glasgow, September 2013

    • Schlanstein PC, Arens J, Borchardt R, Hesselmann F, Jansen SV, Schmitz-Rode T, Steinseifer U, Wagner G: Oxygenator Flow Pattern: PIV of a Fiber Oxygenator.
      Slide presentation at the XXXX. Annual ESAO Congress (European Society for Artificial Organs), Glasgow, September 2013

    • Borchardt R, Schlanstein P, Mager I, Arens J, Schmitz-Rode T, Steinseifer U. Increasing Gas And Heat Exchange By Inducing Physiological Pulsation Into A Heat Exchanging Oxygenator.
      Slide presentation at the 59th Annual Conference of ASAIO (American Society of Artificial Internal Organs), Chicago, June 2013

      2012

    • Schoberer M, Arens J, Erben A, Ophelders D, Jellema RK, Kramer BW, De Brouwer P, Schmitz-Rode T, Steinseifer U, Orlikowsky T. Miniaturisierung als Schlüssel zur klinischen Anwendbarkeit der künstlichen Plazenta.
      Slide presentation at the Joint 108th annual meeting of the DGKJ and 38th annual meeting of the GNPI, Hamburg, September 2012. Conference Proceedings will be prospectively published in Monatsschr Kinderheilkunde

    • Arens J, Schoberer M, Erben A, Orlikowsky T, Ophelders, D, Jellema RK, Kramer BW, De Brouwer P, Schmitz-Rode T, Steinseifer U. NeonatOx: An ECMO System for Use as Artificial Placenta
      Slide presentation at the XXXIX. Annual ESAO Congress (European Society for Artificial Organs), Rostock, Germany,
      September 2012. Proceedings will be published in Int J Artif Organs.

    • Borchardt R, Schlanstein P, Mager I, Arens J, Schmitz-Rode T, Steinseifer U. Development of a Pediatric Oxygenator with Integrated Pulsatile Pump and Heat Exchanger.
      Slide presentation at the 58th Annual Conference of ASAIO (American Society of Artificial Internal Organs), San Francisco, June 2012

      2011

    • Arens J, Schoberer M, Lohr A, Orlikowsky T, Seehase M, Jellema RK, Collins JJ, Kramer BW, Schmitz-Rode T, Steinseifer U. Developing a Pumpless Extracorporeal Lung Support for Premature Neonates (NeonatOx). Biomedizinische Technik/Biomedical Engineering 2011. 56(Supp. 1), Pages 1–11, DOI: 10.1515/bmt.2011.811
      Slide presentation
      at the 45th annual meeting of the DGBTM, Freiburg, September 2011

    • Schoberer M, Arens J, Lohr A, Jellema RK, Seehase M, Erben A, Kramer BW, Schmitz-Rode T, Steinseifer U, Orlikowsky T. Fünf Dekaden im Abseits: Taugt das Prinzip der künstlichen Plazenta zur klinischen Anwendung? Monatsschr Kinderheilkunde 2011;159 (Suppl. 3):233
      S
      lide presentation (e-poster) at the 107th annual meeting of the DGKJ, Bielefeld September 2011

    • Schoberer M, Arens J, Lohr A, Jellema RK, Seehase M, Erben A, Kramer BW, Schmitz-Rode T, Steinseifer U, Orlikowsky T. Lungenassistenz beim Frühgeborenen: Eine künstliche Plazenta im Tiermodell. Monatsschr Kinderheilkunde 2011;159 (Suppl. 3):233
      S
      slide presentation (e-poster) at the 107th annual meeting of the DGKJ, Bielefeld September 2011

    • Borchardt R, Schlanstein P, Mager I, Arens J, Schmitz-Rode T, Steinseifer U. Experimental and Numerical Results of a Neonatal Oxygenator with Integrated Pulsatile Pump and Heat Exchanger
      Slide presentation at the XXXVIII. ESAO Congress, Porto, Portugal, September 2011

    • Borchardt R, Schlanstein P, Mager I, Arens J, Schmitz-Rode T, Steinseifer U. Experimental and numerical results of a neonatal oxygenator with integrated pulsatile pump and heat exchanger.
      Slide presentation at the 45th annual meeting of the DGBTM, Freiburg, September 2011

    • Borchardt R, Schlanstein P, Mager I, Arens J, Schmitz-Rode T, Steinseifer U. In-Vitro Performance Testing of a Pediatric Oxygenator with Integrated Pulsatile Pump.
      Slide presentation at the 57th Annual Conference of ASAIO (American Society of Artificial Internal Organs), Washington, June 2011

    • Arens J, Schoberer M, Lohr A, Orlikowsky T, Seehase M, Jellema RK, Collins JJ, Kramer BW, Schmitz-Rode T, Steinseifer U. NeonatOx – A Pumpless Extracorporeal Lung Support for Premature Neonates. Artif Organs;35(4):A8, S-5
      Slide presentation at the 7th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion, Philadelphia, May 2011
      Awarded with John A. Waldhausen Young Investigator Award

    • Borchardt R, Schlanstein P, Mager I, Arens J, Schmitz-Rode T, Steinseifer U. Experimental evaluation of an oxygenator with integrated pulsatile pump for pediatric applications.
      Slide presentation at the 7th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion, Philadelphia, May 2011

    • Bhavsar S, Seiwert M, Borchardt R, Graefe R, Schlanstein P, Arens J, Schmitz-Rode T, Steinseifer U: Numerical Modeling of Anisotropic Fiber Bundle Behavior in Oxygenators.
      Slide presentation at the 7th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion, Philadelphia, May 2011

    • Schoberer M, Arens J, Lohr A, Seehase M, Jellema RK, Collins JJ, Kramer BW, Schmitz-Rode T, Steinseifer U, Orlikowsky T. 50 years of research on the artificial placenta: are we working on toy or treasure? Artif Organs;35(4):A8, S-8
      Slide presentation at the 7th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion, Philadelphia, May 2011

    • Schoberer M, Arens J, Lohr A, Seehase M, Jellema RK, Collins JJ, Kramer BW, Schmitz-Rode T, Steinseifer U, Orlikowsky T. 50 Jahre künstliche Plazenta – toy or treasure? Monatsschr Kinderheilkunde 2011;159 (Suppl. 2):49
      Slide presentation
      at the 37th annual meeting of the GNPI, Mannheim, May 2011

    • Schoberer M, Arens J, Lohr A, Seehase M, Jellema RK, Collins JJ, Kramer BW, Schmitz-Rode T, Steinseifer U, Orlikowsky T. Extrakorporaler Gasaustausch im Frühgeborenen-Lämmermodell: Die künstliche Plazenta. Monatsschr Kinderheilkunde 2011;159 (Suppl. 2):49-50
      Slide presentation at the 37th annual meeting of the GNPI, Mannheim, May 2011

      2010

    • Schlanstein PC, Borchardt R, Arens J, Schmitz-Rode T, Steinseifer U: Investigation of the influence of pulsating silicone tubes inside an oxygenator.
      Slide presentation at the XXXVII. ESAO Congress, Skopje, R. Macedonia, September 2010

    • Schlanstein PC, Borchardt R, Arens J, Schmitz-Rode T, Steinseifer U: Investigation of the influence of pulsating silicone tubes inside an oxygenator.
      Slide presentation at the XXXVII. ESAO Congress, Skopje, R. Macedonia, September 2010

    • Graefe R, Borchardt R, Arens J, Schlanstein P, Schmitz-Rode T, Steinseifer U: Improving oxygenator performance using computational simulation and flow field-based parameters.
      Slide Presentation at the 6th International Conference on Pediatric Mechanical Circulatory Support Systems and Cardiopulmonary Perfusion, Boston, May 2010

    • Borchardt R, Schlanstein P, Arens J, Graefe R, Schreiber F, Schmitz-Rode T, Steinseifer, U. Description of a flow optimized oxygenator with integrated pulsatile pump
      Slide Presentation at the 6th International Conference on Pediatric Mechanical Circulatory Support Systems and Cardiopulmonary Perfusion, Boston, May 2010

    • H. Schnöring, J. Arens, E. Terrada, J. S. Sachweh, M. Runge, T. Schmitz-Rode, U. Steinseifer, J. F. Vazquez-Jimenez: A Newly Developed Miniaturized Heart Lung Machine − Expression of Systemic Inflammation in a Small Animal Model.           
      Slide Presentation at the 5th International Conference on Pediatric Mechanical Circulatory Support Systems and Cardiopulmonary Perfusion, May 6-8, 2010; Boston, MA, USA

      2009

    • Hormes M, Borchardt R, Behr M, Schmitz-Rode T, Steinseifer U. A Validated CFD Model to Predict O2 and CO2 Transfer within Hollow Fiber Membrane Oxygenators.
      Slide presentation at the XXXVI. ESAO Congress, Compiègne, France, September 2009

    • Arens J; Schnoering H; Pfennig M; Mager I; Vázquez-Jiménez JF; Schmitz-Rode T; Steinseifer U: The Aachen MiniHLM – A Miniaturized Heart-Lung Machine for Neonates with an Integrated Rotary Blood Pump.
      Slide Presentation at the 17th Congress of the International Society for Rotary Blood Pumps (ISRBP), October 1–3, 2009; Singapore

    • J. Arens, H. Schnöring, M. Pfennig, I. Mager, J. Vázquez-Jiménez, T. Schmitz-Rode, U. Steinseifer: The Aachen MiniHLM – A Miniaturized Heart Lung Machine for Neonates with Congenital Heart Defect.   
      Slide Presentation at the World Congress on Medical Physics and Biomedical Engineering, September 07–12, 2009; Munich, Germany

    • Heike Schnoering; Jutta Arens; Joerg S. Sachweh; Melanie Veerman; Rene Tolba; Thomas Schmitz-Rode; Ulrich Steinseifer; Jaime F. Vazquez-Jimenez: The Aachen MiniHLM–first results in a small animal model.    
      Slide Presentation at the 5th International Conference on Pediatric Mechanical Circulatory Support Systems and Cardiopulmonary Perfusion, May 27–30, 2009; Dallas, Texas, USA

      – 2008

    • Jutta Arens; Heike Schnöring; Jaime F. Vázquez-Jiménez; Thomas Schmitz-Rode;  Ulrich Steinseifer: Development of a Miniaturized Heart-Lung-Machine for Neonates with Congenital Heart Defect.          
      Slide Presentation at the 4th International Conference on Pediatric Mechanical Circulatory Support Systems and Cardiopulmonary Perfusion, May 22–24, 2008; Portland, Oregon, USA

    • J. Arens, H. Schnöring, B. Buding, J. Vázquez-Jiménez, T. Schmitz-Rode, U. Steinseifer: Miniaturisierte Herz-Lungen-Maschine – MiniHLM.          
      Slide Presentation at the 41. Jahrestagung der Deutschen Gesellschaft für Biomedizinische Technik im VDE, September 26–29, 2007; Aachen, Germany

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    Posters

      2014

    • Wagner G, Schlanstein P, Borchardt R, Steinseifer U, Arens J: Required gas exchange area and setup of desoxygenators in an in-vivo like test circuit. Poster presentation at the 41st Annual ESAO Congress, Rome, Italy, September 17 – 20, 2014
    • Wagner G, Kaesler A, Schlanstein P, Steinseifer U, Arens J: Current trends in research on oxygenators. Poster presentation at the 25th Annual ELSO Conference, Ann Arbor, MI, USA, September 15 – 18, 2014
    • Hesselmann F, Schlanstein PC, Jansen SV, Schmitz-Rode T, Steinseifer U, Arens J. Flow in a Wound Fiber Membrane Oxygenator: Particle Image Velocimetry for the Validation of Computational Fluid Dynamics.
      Poster presentation at the 60th Annual Conference of ASAIO (American Society of Artificial Internal Organs), Washington, June 2014

      2012

    • Schoberer M, Arens J, Erben A, De Brouwer P, Schmitz-Rode T, Steinseifer U, Ophelders D, Jellema RK, Kramer BW, Orlikowsky T. Miniaturization: The Clue to Clinical Application of the Artificial Placenta. Artif Organs 2012;36(5):A24
      Poster presentation at the 8th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion, June 13-16, 2012; Istanbul, Turkey
    • Arens J, Schoberer M, Erben A, Orlikowsky T, Ophelders, D, Jellema RK, Kramer BW, De Brouwer P, Schmitz-Rode T, Steinseifer U. NeonatOx: An Update on Design, In-Vitro, and In-Vivo Tests. Artif Organs 2012;36(5):A23
      Poster presentation at the 8th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion, June 13-16, 2012; Istanbul, Turkey

      2011

    • Arens J, Schoberer M, Lohr A, Orlikowsky T, Seehase M, Jellema RK, Collins JJ, Kramer BW, Schmitz-Rode T, Steinseifer U: A Pumpless Extracorporeal Lung Assist for Premature Neonates: The Aachen Neonatox. Int J Artif Organs. 34(8): 670, 2011
      Poster presentation at the 4th Joint ESAO-IFAO Congress, October 09-12, 2011; Porto, Portugal
    • Borchardt R; Hormes M; Schmitz Rode T; Steinseifer U: Numerical investigation of the influence of pulsatile flow on gas exchange inside an oxygenator.
      Poster presentation at the 7th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion, Philadelphia, May 2011

      2009

    • Jutta Arens, Heike Schnöring, Jaime Vázquez-Jiménez, Thomas Schmitz-Rode, Ulrich Steinseifer: The Aachen MiniHLM for Neonates with Congenital Heart Defects      
      Poster Presentation at the XXXVI ESAO Congress, Sept 2–5, 2009; Compiegne, France
    • Jutta Arens; Heike Schnoering; Michael Pfennig; Ilona Mager; Jaime F. Vazquez-Jimenez; Thomas Schmitz-Rode; Ulrich Steinseifer: The Aachen MiniHLM – in vitro test results of the new design.          
      Poster Presentation at the 5th International Conference on Pediatric Mechanical Circulatory Support Systems and Cardiopulmonary Perfusion, May 27–30, 2009; Dallas, Texas, USA

      2008

    • Hormes M., Kashefi A., Borchardt R., Schmitz-Rode T., Steinseifer U. CFD Simulation Of Oxygen Transfer In Hollow Fiber Oxygenators.
      Poster presentation at the XXXV. ESAO Congress, Geneva, Switzerland, September 2008

    • Hormes M, Kashefi A, Borchardt R, Schmitz-Rode T, Steinseifer U. A Numerical Model of Oxygen Transfer in Hollow Fiber Oxygenators.
      Poster presentation at the 54th Annual Conference of ASAIO (American Society of Artificial Internal Organs), San Francisco, June 2008

    • Jutta Arens, Heike Schnöring, Fabian Reisch, Jaime Vázquez-Jiménez, Thomas Schmitz-Rode, Ulrich Steinseifer: Development of a Miniaturized Heart-Lung Machine for Neonates with Congenital Heart Defect.  
      Poster Presentation at the ASAIO 54th Annual Conference, June 19–21, 2008; San Francisco, CA, USA

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    Patents

    • Heart-lung machine used in operations comprises a cardiotomy reservoir divided into an upper emergency volume and a lower working volume
      Patent Numbers: DE102007037755-A1; WO2009018920-A1; WO2009018920-A8; EP2173405-A1
      Inventors: Vazquez-Jimenez J, Schnoering H, Schmitz-Rode T, Steinseifer U, Arens J; Patent Assignee and Code: Rheinisch Westfaelische Tech Hochschule (RHEI-Non-standard): RHEIN-WESTFAEL TECH AACHEN EV (RHEI-Non-standard)

    • Exchanger Device
      Patent Number: WO/2012/150233
      Inventors: Steinseifer U, Schmitz-Rode T, Arens J, Schlanstein P, Borchardt R, (DRITTE PATENTPORTFOLIO BETEILIGUNGSGESELLSCHAFT MBH & CO. KG)

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    Group Leader

    Phone: +49 241 80 87018

    E-mail