Respiratory Epithelium and CiliarMechanic
In vivo, respiratory epithelium is subjected to various exogenous influences because of its direct contact to the breathing air. Beside air composition, pressure and flow situation can change due to pathological conditions. These changes can be caused by primary lung diseases as well as by severe changes in breathing mechanics during artificial respiration. Not much is known about the impact of these processes on integrity and function of the respiratory epithelium.
Aim of the CiliarMechanik-project is the examination of the influence of biomechanical variables on development and function of respiratory epithelial in vitro. Ciliary function is analyzed in a two-compartment bioreactor which allows culture with optimally defined and laminar flow conditions. Additionally, this is of high importance to optimize culture of respiratory epithelial cells for Tissue Engineering.